In ex-vivo human studies using
non-anticoagulated blood TT-103MH is able to reduce blood coagulation time in healthy subjects and Haemophilic patients up to 95% (4.5 ± 0.5 minutes to 0.2 ± 0.03 minutes) and 90% (18 ± 1.2 minutes to 1.8 ± 0.3 minutes), respectively. The same potent
procoagulant effects were observed in heparinized plasmas and from patients with coagulation factor deficiencies (Factor V, VII, VIII, IX, X, XI, and XII).